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When the medication stops, these internal drivers resume, appetite returns to baseline, and the body re-gains weight

The increase in intracellular Ca 2+ from approximately 100 nmol/l to approximately 600 to 1000 nmol/l, triggered by glucose, glutamine and asparagine, is similar to that which triggers exocytosis in other secretory cells

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However, the complexity of metabolic and hormonal regulation means that indirect effects cannot be entirely excluded

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