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The linkage of NAD + metabolism to the internal clocks is firstly evidenced by that the NAD(P) + /NAD(P)H ratio modulates the DNA-binding activity of the core oscillators, such as CLOCK: BMAL1 and NPAS2: BMAL1 heterodimers

Efficacy of lifestyle modification combined with GLP-1 receptor agonists on body weight and cardiometabolic biomarkers in individuals with overweight or obesity: a systematic review and meta-analysis

doi: 10.1016/j.neuropharm.2014.06.026 118 LeonardB

IR is associated with chronic low-grade inflammation, hypothalamicpituitaryadrenal (HPA) axis dysregulation, impaired neuroplasticity, mitochondrial dysfunction, and altered reward processing mechanisms that may contribute to core depressive features such as anhedonia, cognitive slowing, and emotional dysregulation

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