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People have lost 10-22.5% of their body weight in trials

Cost can be one of the biggest hurdles

GLP-1 drugs are a hot topic for a reason: They can help with weight management and type 2 diabetes

Gilead Sciences last year dropped a Phase II (NCT04971785) program to develop the Nimbus-discovered acetyl-CoA Carboxylase (ACC) inhibitor firsocostat (formerly GS-0976 and NDI-010976), in combination with semaglutide and another Gilead candidate, cilofexor, in cirrhosis due to metabolic dysfunction-associated steatohepatitis (MASH)

After repeatedly communicating distress

Some users prefer starting small, testing a few low-stakes rounds, and reviewing detailed histories