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26 Fasting-related headaches also merit consideration

Imaeda says

2017;25:20 Lu Y, Wu L, Lin M, Bao X, Zhong H, Ke P, et al

Front Immunol 2023

Additionally, GLP-1 signaling appears to influence stress response systems and emotional regulation, which are important factors in addiction vulnerability and relapse

Of note, even before the introduction of the newer classes of medications, multifactorial, target-driven therapies addressing glycaemic, blood pressure and lipid control that incorporated reninangiotensin system blockade, the use of statins and attention to lifestyle factors significantly reduced the progression to end-stage kidney disease by about 50% in people with type 2 diabetes, hypertension and microalbuminuria