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Understanding individual triggers and patterns helps inform personalised management strategies

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PNPLA3 has hydrolase activity on triglycerides, and the I148M genetic variant is associated with a functional loss of this activity, which promotes the accumulation of triglycerides in hepatocytes and favors the development of hepatic steatosis 62

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[DOI] [PubMed] [Google Scholar] 127.EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD) Obes Facts