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Description
Discover how GLP-1 agonists help improve cardiovascular outcomes independently of glucose control.

Maria Kalaitzandonakes, Brenna Ellison, Trey Malone, and Jonathan Coppess - Maria Kalaitzandonakes -

Eli Lilly's orforglipron, the first small-molecule GLP-1 pill, transforms diabetes treatment with oral convenience and new patent strategies.

Reduce the risk of heart failure exacerbations by 40% and hospitalizations by 33%
Mechanistic hypotheses include reduced leptin-driven T-helper (Th)1/Th17 activity, improved adipokine balance, and modulation of gut-thyroid axis pathways

In a recent Managed Healthcare Executive pharmacy survey, plan sponsors, []