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Begin Your Trial Start your one-week trial, then return for ongoing follow-ups to fine-tune your plan

They work centrally in the brain, particularly the hypothalamus, to: Reduce hunger signals Increase satiety Improve control over eating They also act peripherally, affecting gut hormones, insulin, glucagon, and fat metabolism

Proper storage preserves medication potency

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Contrave uses a dual-mechanism approach to weight loss, combining two medications that target different pathways in the brain

In the Phase 2 trial, this approach resulted in net improvements in glycated hemoglobin and fasting glucose across all dose groups, confirming that the three receptors balance each other when introduced gradually