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Patients typically lost 18-20% of their body weight over one year 34 , helping reduce airway obstruction

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The retinal capillary damage central to DR leads to tissue hypoxia, altered venous oxygen saturation, and a compromised ability to regulate blood flow [87,88,89]

There is a relentless push from the medical community to have obesity universally recognized and treated as a chronic disease, just like diabetes or hypertension

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None of the compounds caused changes in testosterone levels, except for a modest but significant increase in GLP1-treated PWA mice (Fig