glp 1 agonist in ckd GLP-1 Receptor Agonists and Kidney Protection GLP-1 receptor agonists effects on

Vascular located monocytes/macrophages engulf oxidized-LDL (ox-LDL), generating foam cells which release a plethora of pro-inflammatory mediators

GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

Kidney Int 2022;102:97489

How is GLP-1 Naturally Produced in the Body, and Why is it Important

Acute pancreatitis, gallbladder disease, and stomach paralysis have also been rarely reported with GLP-1 use

Among patients with Type 2 diabetes, weight reduction averaged only 23% after 72 weeks