glp-1 produced by GLP-1: Actions on Beta-cell Mass and Function GLP-1 | Pancreapedia
Description
Kim MK, Baek KH, Song KH, Il Kang M, Park CY, Lee WY, et al
As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life ( A prospective clinical study from Spain found that besides controlling blood glucose (fasting blood glucose and glycosylated hemoglobin), LIXI can also improve blood lipids, especially total cholesterol and triglyceride ( In clinical studies, LIXI has shown the benefits of weight loss, which is well tolerated by patients and can meet the needs of overweight patients for weight control
doi: 10.1007/s00125-018-4810-0 59 ElKCampbellJE
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Lancet 403 , 10271050 (2024)
