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doi:10.1152/ajpendo.00069.2016 Gupta NA, Mells J, Dunham RM, et al

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Both drugs prevented MPTP-induced motor impairment, protected dopaminergic neurons in the substantia nigra, reduced the expression of the proapoptotic signaling molecule Bax, and increased the levels of the antiapoptotic molecule Bcl-2 [87]

The energy requirements of the brain are very high due to energy intensive processes that are essential for healthy brain function, such as maintenance of ion gradients, cellular signalling, synaptic vesicle trafficking, and uptake and recycling of neurotransmitters [190]