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Description
Testosterone replacement therapy (TRT) works by restoring hormone levels to normal ranges, which can modestly improve metabolic function and lean muscle preservation
Any potential mood benefits should be considered an additional effect rather than a primary therapeutic goal

However, a 2023 review described rare preliminary amphetamine false positives due to Sildenafil

Synthesis and Secretion of GLP-1 and GIP K-Cell (jejunum) L-Cell (ileum) ProGIP Proglucagon GIP [1-42] GLP-1 [7-37] GLP-1 [7-36NH2] 100 | 20 | 40 | 100 | 160 80 15 60 10 40 Intact GIP (pmol/L) Intact GLP1 (pmol/L) 5 20 0 0 | 20 | 40 | 100 | 160 Time (min) Time (min) Secretion of Incretins After Meals GIP GLP1 50 200 40 150 30 100 Total GLP1 (pmol/L) Total GIP (pmol/L) 20 50 10 0 0 20 Vilsboll T, et al

Some call these medications "generic Ozempic" (they're not)

These typically occur when starting the medication or increasing the dose and often subside as the body adjusts
