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Both these receptors are activated by similar types of short chain fatty acids (292), and both these signal through an inhibitory G type protein, but FFAR2 is also capable to signal through Gq/11 proteins (293) by which it has shown to mediate GLP-1 and PYY secretion in vitro and in vivo (82, 295)

When starting GLP-1 RAs, these findings suggest the need for individualized medicine strategies, which may include careful patient selection, risk-benefit analyses, and possibly introducing earlier or more frequent colorectal cancer screening for high-risk patients

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doi: 10.3390/biomedicines11082127

Source: Bartelt, et al Epic Research Network October 10, 2023 LIN K Implications for employers: An FDA black box warning says that those with a family or personal history of medullary thyroid cancer should not be prescribed GLP-1 drugs

Being well-hydrated can reduce water retention and support overall metabolism