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Description
Our investigation identifies new potentially druggable locations in the receptor, expanding the existing repertoire of functionally relevant sites for the rational design of novel GLP-1R allosteric modulators based on the modulation of receptor-cholesterol interactions

The application includes the drugs liraglutide, dulaglutide, semaglutide, and tirzepatide

Beyond weight loss, these medications offer protection against conditions that impact millions of people worldwide

Similarly, a systematic review addressing the perioperative management of diabetic patients endorsed the maintenance of GLP-1RAs treatment on the day of surgery.179 In a single-center retrospective cohort study by Stark et al180 involving patients undergoing esophagogastroduodenoscopy, most of whom had T2DM, 56% received dulaglutide, 37% liraglutide, and 5% exenatide

Experts have long known that biological aging can be slowed down with a good diet, regular exercise and avoiding alcohol and drugs

The prevalence of NAFLD varies significantly between different geographic areas and by ethnicity [1, 2]
