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Baseline evaluation with dilated fundus examination prior to or shortly after GLP-1 RA initiation is recommended, particularly in patients with more advanced diabetic retinopathy

Several GLP-1 receptor agonists have also demonstrated cardiovascular benefits in patients at high risk, although this is not a universal finding, as described later (2430)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Li C, et al

The leptin-melanocortin axis, the opioid system, glucagon-like peptide-1 (GLP-1)/glucagon-like peptide-1 receptor (GLP-1R) system, and fibroblast growth factor 21 (FGF21)/its receptor complex FGFR1c/-klotho axis are several common pathways confirmed by researches and pharmacological targets that play an essential role in regulating energy balance and feeding behavior (2)