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If a beta-blocker is combined, a vasodilator beta-blocker, including Carvedilol or Nebivolol, may be preferred because non-vasodilator beta-blockers accelerate albuminuria progression ( In patients with DKD, SGLT2i or MRA can be added when the target urinary albumin levels are not achieved with RAS blockade (Piperidou et al., 2019)

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