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If dopamine tone is running low, a person may pursue larger reward hits just to feel stable

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Semaglutide is a GLP-1 receptor agonist that helps support weight management by regulating appetite, reducing cravings, stabilizing blood sugar levels, and encouraging gradual fat loss

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Subjects were excluded if they had clinically significant concomitant diseases or disorders, clinically significant abnormal values in laboratory screening tests, any history of gastrointestinal surgery (except uncomplicated surgical procedures such as appendectomy and hernia surgery), or if they smoked more than five cigarettes or the equivalent per day