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Materials and methods: ADAR2 +/+ /GluR-B R/R mice (wild type [WT]) and ADAR2 -/- /GluR-B R/R mice (ADAR2 knockout [KO]) were used to investigate the in vivo roles of ADAR2 in regulation of glucose homeostasis and pancreatic cell function during the progression of type 2 diabetes mellitus (T2DM)