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Some patients benefit from numbing creams like topical lidocaine applied 20-30 minutes before injection, though this adds cost and preparation time

In clinical trial protocols, the drug is initiated at a low dose and titrated gradually upwards to minimise gastrointestinal side effects

Abstract Objective: To compare the efficacy of lorazepam and diazepam in managing alcohol withdrawal and associated anxiety and depressive symptoms in alcohol dependence syndrome

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Important safety considerations include a boxed warning for thyroid C-cell tumors, contraindication in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and precautions regarding pregnancy (not recommended), reduced oral contraceptive effectiveness, and risks of pancreatitis, gallbladder disease, and acute kidney injury

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