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While weight loss may provide significant joint symptom relief over time, this benefit typically emerges gradually over months as weight reduction accumulates
DPP-4 converts BNP1-32 into its inactive form BNP3-32 (106) and can attenuate the diuretic and natriuretic effects of BNP1-32 (107)
Several factors contribute to this inconsistency
This step is essential, as both drugs are available by prescription only
Trial data from STEP 4 (semaglutide) and SURMOUNT-4 (tirzepatide) show most of the weight is regained over 5288 weeks after discontinuation
