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The American Journal of Psychiatry 2003;160(1):112117

Phentermine is a sympathomimetic amine stimulant, not a GLP-1 receptor agonist

Their mechanism of action involves several complementary pathways: Enhancing glucose-dependent insulin secretion from pancreatic beta cells, which helps lower blood glucose levels when they are elevated Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which moderates the rate at which nutrients enter the bloodstream Promoting satiety through central nervous system effects, leading to reduced appetite and caloric intake These combined effects result in improved glycaemic control in people with type 2 diabetes and significant weight loss in those using higher doses for obesity management

In the SURMOUNT-1 trial, participants on the highest dose lost an average of 22.5% of their body weight over 72 weeks, with over half achieving at least 20% weight loss

A recent 2024 multisociety guidance document provides recommendations for patient optimization prior to a procedure utilizing sedation or general anesthesia

Contact Klinic to work with a weight loss specialist who will find the right treatment for you, including one with the fewest side effects