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Pivotal trials like STEP 1 and STEP 2 showed semaglutide produces 510% body weight reduction over 68 weeks, with meaningful loss appearing by week 4 in most participants

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When dark urine does occur in Ozempic users, it most commonly appears during these initial weeks or following dose increases

doi: 10.1016/j.jad.2016.09.056 13 KuchayMSKrishanSMishraSKChoudharyNSSinghMKWasirJSet al

[16] Hypercholesterolemia was reported in 3.5% of postmenopausal women with operable breast cancer who received adjuvant tamoxifen therapy (n = 3094) in the ATAC trial