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Moreover, our data reveal novel aspects of GLP-1 stimulated insulin secretion involving de novo gene expression.

Tirzepatide has demonstrated strong safety outcomes in clinical trials with weight loss benefits exceeding traditional GLP-1 medications

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Background Oral semaglutide is a novel glucagon-like peptide-1 (GLP-1) analog that has been associated with improvements in glycated hemoglobin (HbA1c) and body weight versus sodium-glucose cotransporter-2 inhibitor empagliflozin and injectable GLP-1 receptor agonist dulaglutide in the PIONEER 2 clinical trial and in a recent network meta-analysis (NMA), respectively

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