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This group of PIONEER studies was important in demonstrating that oral SMG is effective for controlling glycemia and reducing weight in patients with DM2 [68,76,78,79,80,81,82,83] and as a non-inferior option compared to injectables for glycemic control [84,85,86]

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Different macronutrients stimulate GLP-1 secretion to varying degrees: Fiber and complex carbohydrates : Dietary fiber, particularly soluble fiber, enhances GLP-1 secretion by slowing nutrient absorption and allowing more prolonged contact with L-cells in the distal intestine