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A recent secondary analysis of a randomized controlled trial looked at adults with obesity, without diabetes, who first completed an 8 week low calorie diet and were then assigned to one of four groups for 52 weeks

They pay 180 out-of-pocket for a months supply, which their travel insurance partially reimburses

Conclusion The study found that GLP-1RA therapy is effective not only in managing blood glucose levels in individuals with type 2 diabetes but also in reducing body weight in obese individuals and changing unhealthy eating tendencies, such as the tendency to eat in response to external food cues (external eating)

DeFronzo RA, Stonehouse AH, Han J, Wintle ME

Brain Imaging of the GLP-1 Receptor in Obesity Using 68Ga-NODAGA-Exendin-4 PET

Semaglutide reduced MACE by 20% compared to placebo over a median follow-up of 33 months