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This prolonged retention might increase intragastric pressure and potentially promote retrograde movement of gastric contents into the esophagus, particularly in patients with pre-existing lower esophageal sphincter dysfunction or hiatal hernia

Figure 3 GLP-1RAs compared to placebo A total of six RCTs (674 belonged to the GLP-1RAs group and 670 to the placebo group) compared the change in HbA1c from baseline to follow-up in patients with T2DM ( 2 = 77%) ( Figure 4A )

2012;43(3):e11-e18

There are no tiered pricing structures, no surprise fees for higher doses, and no additional charges as treatment progresses

One risk that has gained attention with these medications is their possible link to gastroparesis or delayed stomach emptying

Those are the variables that shape the outcome