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Frizzled-7-targeting antibody (SHH002-hu1) potently suppresses non-small-cell lung cancer via Wnt/-catenin signaling

This can be achieved by crossing the blood-brain-barrier involving saturable mechanisms (Banks et al., 2002), by diffusing through fenestrated capillaries at circumventricular organs (Uriarte et al., 2021), or by crossing the blood-cerebrospinal barrier (Uriarte et al., 2019)

Kittleson shares pearls of wisdom from her book on topics including career transitions, mentorship, dealing with uncertainty, learning from mistakes, delivering difficult news, and being a woman and parent in medicine

Advanced GLP-1 Therapy Options GLP-1 (Glucagon-Like Peptide-1) receptor agonists have revolutionized medical weight management by safely targeting the brain's appetite centers, reducing intense "food noise," and slowing gastric emptying so you feel full longer

Of the 286 AE reports with available information on age, the median age of patients was 56 years [interquartile range (IQR) = 4867]

doi: 10.1136/bmj.l5119