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Clinical trials have shown that injectable GLP-1 agents generally produce slightly greater reductions in HbA1c

Lee: Patient behavior can absolutely play a role
Nathan BM, Rudser KD, Abuzzahab MJ, Fox CK, Coombes BJ, Bomberg EM, et al

Still, others find the side effects unmanageable or find the medications to be ineffective
However, despite only differing by 2 of the 39 residues (Gly 2 , Glu 3 in Ex4, compared with Ser 2 , Asp 3 in exendin-3), Ex4 was found to have distinct pharmacological properties and does not act at VIP or secretin receptors
