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Comorbidities and pathomechanisms that lead to additional increases in cardiac filling pressures accelerate the age-related deterioration in diastolic function

It is classified by left ventricular ejection fraction, a key prognostic factor

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Unlike conventional therapies that require multiple single-dose pens during dose escalation, this system allows patients to administer varying doses using a single reusable pen with a prefilled cartridge.This approach is expected to enhance patient convenience, improve treatment adherence, and reduce overall therapy costs