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Lauren Grawert, MD, clinical advisor at The Garden New Jersey, said its believed that GLP-1 medications can provide psychiatric benefits because they can cross the blood-brain barrier and bind to brain regions associated with the reward system

Access to injectable (compounded) semaglutide is sourced from audited and licensed US-based compounding pharmacies

It has a 1.9% weighting in Tema's fund and a market cap of $8.5 billion

In recent years, GLP-1RA and DPP4-i therapies are known to have pleiotropic effects, such as a reduction in oxidative stress, autophagy regulation, metabolic reprogramming, enhancement of anti-inflammatory signaling, regulation of gene expression, and being neuroprotective

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Further randomised controlled and pragmatic trials are needed to define their potential benefits/harms, mechanisms of action and where GLP1RAs might fit into existing treatment pathways for uncontrolled asthma
