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The popularity of GLP-1 M is partly due to its cardiovascular, kidney, and weight loss benefits

Some agents in this class (including liraglutide, semaglutide, and dulaglutide) have demonstrated significant reductions in major adverse cardiovascular events (MACE) in dedicated cardiovascular outcome trials

Many patients switch from Wegovy to Zepbound for stronger weight loss results, often after a treatment plateau

In contrast, oral medications face a first-pass challenge
