is bupropion a glp-1 Semaglutide vs Contrave: vs Naltrexone/Bupropion Bupropion for Weight Loss: How

Kim et al., 2020)

The pleiotropic effects of sodium-glucose cotransporter-2 inhibitors: beyond the glycemic benefit

Prem J Sci 2025;10:100082

Although the mechanism of this proposed uncoupling event has not been fully elucidated, our understanding of the GLP-1R signalling cascade suggests that SUs may allow GLP-1R agonists to bypass glucose dependence by triggering -cell depolarization even in the absence of glucose

These studies all showed that GLP-/GIP dual agonists had similar effects on lipid metabolism to GLP-1, and even had better effects on lipid reduction and weight loss

Every person responds differently based on genetics, nutrition, overall health, the amount of weight lost, and how quickly that weight is lost