why is semaglutide so expensive Medicare launches weight loss drug option with $50 copay : NPR How Much Do Ozempic and
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Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex

Acarbose, an AGI, has been shown in pre-clinical models to increase lifespan (greater longevity benefits in males), with decreased body weight gain independent of calorie intake reduction

Here is how they compare
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Pharmacovigilance analyses identified disproportionate reporting signals for dyspnoea and asthma-like events, particularly with exenatide, using the reporting odds ratio (ROR 2.14, 95% CI 1.882.43

This amount of weight loss has not been accomplished before with medical therapy
