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What the clinical trial numbers do not capture is the real-world experience where many patients on various semaglutide doses report sulfur burps that come and go, particularly in the first few weeks and after dose escalations

The Phase 2 retatrutide trial in obesity (Jastreboff et al., NEJM 2023) hit 24.2% at 48 weeks

It is telogen effluvium - a temporary disruption of the hair growth cycle triggered by the physiological stress of rapid weight loss, identical to what occurs after childbirth, major surgery, or crash dieting

Orekhov, Tannaz Jamialahmadi, Amirhossein Sahebkar Current Medicinal Chemistry.2025

Most fatigue during GLP-1 therapy stems from reduced calorie intake or rapid weight loss rather than the medication directly

A February 2026 Northwestern University study published in Neuroscience of Consciousness pushed that idea further, showing that targeted sound cues during REM sleep could actually steer dream content