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Alcohol, scrolling, TV and easy access to snack foods can add another layer of cueing

GLP-1 also induces a rapid cAMP-dependent activation of extracellular signaling kinase, ERK1/2, and a delayed -arrestin [an adaptor protein necessary for GLP-1r signaling (216)]-dependent increase of ERK1/2 signaling (186)

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"And that inflammatory state results in organ damage that leads to cardiometabolic disease, kidney disease, diabetes, certain forms of cancer, and potentially certain neurodegenerative changes," says Kessler

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Dose control: High doses may cause joint swelling (due to excessive muscle growth compressing the joints), and an individualized dose plan needs to be established