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doi:10.1001/jamanetworkopen.2019.20745 Biondi B
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In the SURPASS 1-5 trials, different dosages of Tirzepatide (5 mg, 10 mg, and 15 mg) demonstrated significant weight reduction in obese patients with type 2 diabetes mellitus (T2DM), especially when compared to placebo (SURPASS 1) (25), semaglutide 1 mg (SURPASS 2) (26), insulin degludec (SURPASS 3) (27), insulin glargine (SURPASS 4) (28), and placebo+ insulin glargine (SURPASS 5) (29)
[Accessed on 11 June 2026] Q4 2025 / Full Year 2025 Investor Presentation
For example, any information (eg, on adverse effects) that was not reported by the patient or entered into the EMR portal by the health care professional could potentially be missed
The severity and duration of gastrointestinal symptoms vary considerably between individuals
