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Absolute contraindications include personal/family history of medullary thyroid cancer, MEN2, severe pancreatitis, or GLP-1 allergy

These are taken daily and designed to deliver similar appetite-regulating effects as the injectable versions

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For example, taking your weekly semaglutide injection on a Friday night might allow you to weather any weekend GI side effects at home rather than on a workday

In fact, the similar pathological mechanisms shared by PD and T2DM have inspired several studies on the therapeutic potential of T2DM drugs against PD, among which glucagon-like peptide-1 receptor (GLP-1R) agonists are promising candidates