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Through activation of GLP-1R signaling, semaglutide enhances glucose-dependent insulin secretion, improves glycemic control, and modulates pathways involved in appetite regulation and energy balance

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Patients with type 2 diabetes who are about to begin, or who have recently begun, taking a GLP-1 drug should have a baseline dilated eye examination to determine their level of DR

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Beyond T2D and obesity, semaglutide was also applied for other indications such as cardiovascular disease, fatty liver, chronic kidney disease, all of which have progressed to Phase 3, expanding the influence of GLP-1RAs into more medical fields

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