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Although these mechanisms have been exploited to facilitate weight loss, these medications have also been indicated for patients with cardiovascular or renal diseases, all of which have caused a recent drastic rise in prescribing GLP-1 RAs

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Researchers have been discovering new health benefits of the drugs used to treat diabetes and obesity.

Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide

A new case report highlights the potential risk of "anhedonia" from high doses of tirzepatide, though it can be treated effectively.

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