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Despite these differences among individuals prescribed different GLP-1 RAs, those prescribed semaglutide, like the overall GLP-1 RA group, were more likely to be diagnosed with T2D at a younger age, female, and obese compared to those prescribed SGLT2is and DPP4is (Table S1)

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A key limitation of this study is the lack of a weight-matched control group (e.g., mice on a calorie-restricted diet), which would help determine whether the observed behavioural changes are directly due to semaglutides central effects or simply a consequence of weight loss