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In findings from the STEP TEENS phase 3a trial, adolescents aged 12 to 17 years with obesity or overweight and at least one weight-related coexisting condition were randomly assigned 2:1 to receive semaglutide 2.4 mg (Wegovy, Novo Nordisk) or placebo for 68 weeks

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Abbreviations CVD: Cardiovascular disease T2D: Type 2 diabetes CV: Cardiovascular HF: Heart failure GLP-1RA: Glucagon-like peptide 1 receptor agonist SGLT-2: Sodium-glucose cotransporter 2 MACE: Major cardiovascular events MI: Myocardial infarction ADA: American Diabetes Association HFrEF: Heart failure with reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction FDA: Food and Drug Administration NHANES: National Health and Nutrition Examination Survey CKD: Chronic kidney disease References Grundy SM, Benjamin IJ, Burke GL, et al

From a mechanistic standpoint, the ability of retatrutide to sustain benefits over many months likely reflects both its pharmacokinetic profile and its triple-agonist mechanism

Clinical trials have demonstrated substantial weight losswith mean reductions up to approximately 21% of body weight at 72 weeks in the SURMOUNT-1 trialalongside meaningful improvements in hemoglobin A1c levels in patients with diabetes