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Treatment with glucagon-like peptide-1 receptor agonists significantly reduced alanine aminotransferase among children with metabolic dysfunction-associated steatotic liver disease, especially those with type 2 diabetes.“MASLD is the most common chronic liver disease in children, the rates continue to rise and is the fastest growing indication for liver transplant

In the absence of ligand, a Negative Regulatory Region (NRR) in the Notch ectodomain adopts an autoinhibited confirmation, masking an ADAM protease cleavage site [[1][1], [2][2]]

The retrospective data should encourage prospective trials in this space, Arman Qamar says.

Medical weight management with GLP-1 agonists including Ozempic and Wegovy