glp-1 agonists ozempic Is the Same as Ozempic? Is GLP-1 Safe for Weight

J Bone Miner Res 33:975986 Shanbhogue VV, Stving RK, Frederiksen KH et al (2017) Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study

PMID: 15561911

Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)

Sanada, J

[93] advocated for a multimodal approach that includes nutritional optimization, volume restoration, skin resurfacing, and surgical intervention when indicated

Although addressing obesity can be challenging, all healthcare professionals should discuss a patients weight in a sensitive, nonjudgemental manner (Box 2)