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Tunio MA, Alasiri M, Riaz K, Alshakweer W

Aliment Pharm

Patients learn how the titration schedule improves tolerability, what to expect at each stage, and how side effects can be managed effectively

It is proposed that GLP-1 signaling may enhance mitochondrial biogenesis through the PGC-1/nuclear respiratory factor-1/mitochondrial transcription factor A pathway, regulated by adiponectin/AMP-activated protein kinase (AMPK), and increase the expression of NAD-dependent protein deacetylase sirtuin 1 (SIRT1), which upregulates Parkin expression, thereby promoting mitophagy [37]

Pancreatitis There have been reports of acute pancreatitis (inflammation of the pancreas) in patients taking GLP-1 receptor agonists

Tirzepatide offers the best balance of proven results, availability, and tolerability