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These latter AEs were more common in the anti-ActA and combination groups, and while these are difficult to assess in rodents and primates, we did not observe any of these in any of our preclinical in vivo studies

Differently, administration of Citrobacter rodentium , a bacterium able to disrupt the epithelial barrier, in NOD mice, could increase intestinal permeability, leading to pancreatic insulitis development [60]