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The proportion achieving 5%, 10% and 15% weight loss rose steadily with increasing dose (6194%, 22 80% and 1058%, respectively)

(The Lancet eClinicalMedicine, 2025) And here's the uncomfortable finding: the intensity of behavioral support given alongside the medicine didn't reliably change how much weight came back

In patients with baseline eGFR below 60 mL/min per 1.73m2, a relevant and high-risk group, there were dose-dependent reductions in eGFR decline of 22 to 28%

AOD-9604 Side Effects AOD-9604 is remarkably well tolerated