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Furthermore, loss of lean muscle mass, which can occur alongside fat loss if protein intake and resistance exercise are inadequate, further reduces metabolic heat production since muscle tissue is metabolically active and generates significant body heat even at rest

Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

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Fatty acid oxidation was increased with drug treatment while carbohydrate oxidation was lower (Fig

Patients often report decreased cravings for high-fat and high-sugar foods, making it easier to adhere to healthier eating patterns