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Semaglutide targets only GLP-1 receptors , while tirzepatide activates both GLP-1 and GIP receptors simultaneously

In the STEP 1 trial, adults with overweight or obesity who used once-weekly semaglutide 2.4 mg plus lifestyle intervention lost an average of 14.9% of baseline body weight by week 68 , compared with 2.4% in the placebo group

Always discuss persistent or severe side effects with your healthcare provider

Cost comparison: the price gap is enormous If cost were the only factor, this comparison would be over before it started

But now that both are widely available, a common question keeps coming up: which one actually works better

However, those with insurance may see reduced costs, with negotiated rebates bringing the price down to around $530 per month