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Data Analysis Concentrations of Exendin-4-Fc and insulin were calculated using a four-parameter algorithm

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Insulin has also been suggested to play a significant role as a paracrine regulator of glucagon secretion (the intra-islet hypothesis), although the mechanism by which this inhibition occurs is not well elucidated (133)

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Since that initial phase 2 publication in 2023, the evidence base has expanded substantially