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Obesity is also associated with both increased PsA incidence and reduced therapeutic response to biologic agents (23, 24)

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Mechanism of action of DPP4 inhibitors The action mechanism of Dipeptidyl peptidase-4 (DPP4) inhibitors revolves around inhibiting the activity of DPP4, the enzyme responsible for degrading incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

The separation challenge : The chromatographic impact of oxidation varies significantly depending on the specific residue involved: Methionine sulfoxide : Generally elutes earlier than the native peptide in RPLC due to the increased polarity of the oxide group